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Captopril in Human Blood and Breast Milk
Author(s) -
DEVLIN RICHARD G.,
FLEISS PAUL M.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb01759.x
Subject(s) - captopril , breast milk , medicine , human breast milk , pharmacology , cardiology , blood pressure , chemistry , biochemistry
Blood and milk concentrations of captopril, a new antihypertensive agent, were studied in 12 lactating normotensive subjects after the administration of 100 mg captopril tablets on a three times daily regimen for a total of seven doses. Peak blood concentrations (± S.E.M.) of captopril after the administration of the seventh 100‐mg tablet averaged 713.1 ± 140.6 ng/ml, as compared to average peak milk concentrations of 4.7 ± 0.7 ng/ml. Time to peak blood concentrations averaged 1.1 ± 0.2 hour, while time to peak milk concentrations averaged 3.8 ± 0.6 hours. The data suggest that the human breast selectively restricts the passage of captopril from blood into milk.