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Steady‐State Lithium Blood Level Fluctuations in Man Following Administration of a Lithium Carbonate Conventional and Controlled‐Release Dosage Form
Author(s) -
CALDWELL HENRY C.,
WESTLAKE WILFRED J.,
SCHRIVER ROBERT C.,
BUMBIER EDGAR E.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb01758.x
Subject(s) - lithium carbonate , lithium (medication) , steady state (chemistry) , medicine , pharmacology , chemistry , ion , organic chemistry , ionic bonding
A controlled‐release lithium carbonate tablet was compared to an immediate‐release lithium carbonate capsule in normal volunteers. These crossover studies at steady state showed that the tablet produced a smoother serum curve than the capsule with no loss of total bioavailability. Quantitatively, the capsule produced about 1.4 times more fluctuation in serum lithium values than the tablet.