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Synergistic Effects of Probucol and Cholestyramine to Lower Serum Cholesterol
Author(s) -
BOYDEN THOMAS W.,
TOTMAN LAWRENCE
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb01732.x
Subject(s) - probucol , cholestyramine , cholesterol , medicine , endocrinology , chemistry
Ten men with hypercholesterolemia were treated sequentially with a fat‐modified diet, a diet plus probucol (1 Gm/day), and a diet plus probucol plus cholestyramine (16 Gm/day). Each treatment period was 12 weeks. Diet alone reduced mean serum cholesterol by 1.0 per cent. Diet plus probucol caused a mean 7.7 per cent reduction in serum cholesterol below the baseline values ( P = 0.001 compared to diet). Adding cholestyramine to probucol and diet resulted in a mean 18.2 per cent reduction in serum cholesterol below baseline values ( P = 0.001 compared to probucol and diet). The treatment was well tolerated.