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A Comparison of Dopamine Receptor Blocking Assay with Plasma Drug Levels of Haloperidol in Schizophrenic Patients
Author(s) -
KURLAND ALBERT A.,
NAGARAJU ARRAMRAJU,
HANLON THOMAS E.,
WILKINSON EDWINA H.,
NG KUNGTAT
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb01731.x
Subject(s) - haloperidol , pharmacology , dopamine antagonist , dopamine , dopamine receptor , blocking (statistics) , dopamine receptor d2 , drug , chemistry , plasma levels , plasma concentration , medicine , chromatography , statistics , mathematics
A comparison of a chemical analytic technique (gas chromatography/mass spectrometry) with that of the dopamine receptor blocking assay in a study involving seven schizophrenic patients being administered a fixed dosage of haloperidol (20 mg) demonstrated a high degree of correspondence in the quantification of the plasma levels of the neuroleptic.