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Albumin‐Binding Interactions of Sodium Valproate
Author(s) -
FLEITMAN J. S.,
BRUNI J.,
PERRIN J. H.,
WILDER B. J.
Publication year - 1980
Publication title -
the journal of clinical pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1980.tb02544.x
Subject(s) - pharmacology , albumin , chemistry , phenylbutazone , warfarin , carbamazepine , plasma protein binding , serum albumin , human albumin , dialysis , sodium salicylate , sodium , human serum albumin , in vitro , chromatography , medicine , biochemistry , epilepsy , organic chemistry , psychiatry , atrial fibrillation
In vitro equilibrium dialysis experiments show that salicylate and phenylbutazone displace valproate from its binding sites on human serum albumin at therapeutic concentrations, whereas warfarin and carbamazepin do not.