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The Analgesic Effect of Intravenous Indoprofen and Lysine Acetylsalicylate in Patients with Postoperative Pain 1
Author(s) -
CATTANEO ANGELO DOMENICO,
ROCCATAGLIATA DINA
Publication year - 1980
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1980.tb01721.x
Subject(s) - analgesic , medicine , anesthesia , pain relief
Indoprofen, as isoindolinyl derivative, was evaluated as a postoperative analgesic in a randomized double-blind, between-patients study on 40 men with postgastrectomy pain. Single intravenous doses of 100 and 300 mg indoprofen and 0.5 and 1.5 Gm lysine acetylsalicylate (ASA) were compared in a four-point assay. The method of evaluation relied on subjective appraisal of pain relief by the patient for 6 hours after medication. The results demonstrate the analgesic efficacy of indoprofen in patients with severe postoperative pain, a dose-dependent effect, and a 13-to-16 potency ratio to ASA as judged from total pain relief.