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Plasma Levels of Clobazam after 10‐, 20‐, and 40‐mg Tablet Doses in Healthy Subjects
Author(s) -
VALLNER J. J.,
KOTZAN J. A.,
STEWART J. T.,
HONIGBERG I. L.,
NEEDHAM T. E.,
BROWN W. J.
Publication year - 1980
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1980.tb01717.x
Subject(s) - clobazam , bioavailability , medicine , ingestion , plasma concentration , pharmacology , pharmacokinetics , plasma levels , half life , anesthesia , psychiatry , epilepsy
It is evident that substantial intersubject and intrasubject varition in the bioavailability of clobazam exists following ingestion of 10, 20 and 40 mg doses in these 12 volunteers. Peak concentrations and area under the plasma level-time curve were directly proportional to the dose of clobazam and the mean plasma half-life of clobazam was about 18 hours regardless of dose administered. The t1/2 value was less than that previously reported, as the current results allow differentiation of parent drug from metabolites. This 18 hr t1/2 compares favorably with the half-life of other benzodiazepines.