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Fentanyl Pharmacokinetics in Awake Volunteers
Author(s) -
FUNG DENNIS L.,
EISELE JOHN H.
Publication year - 1980
Publication title -
the journal of clinical pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1980.tb01682.x
Subject(s) - anesthesiology , droperidol , medicine , library science , fentanyl , anesthesia , computer science
A single intravenous dose of fentanyl (either 2 or 4 micrograms/kg body weight) was given to 13 healthy, young volunteer subjects. Serum fentanyl concentration decreased in a triexponential pattern. The terminal half-times were 750 and 853 minutes, respectively. A three-compartment, open, mammillary model is proposed for fentanyl kinetics.