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Mathematical Considerations in the Estimation of Peak Drug Concentrations Under Uniform and Nonuniform Dosing Conditions
Author(s) -
HULL J. HEYWARD
Publication year - 1980
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1980.tb01681.x
Subject(s) - chapel , hull , library science , dosing , pharmacy , medicine , operations research , computer science , mathematics , history , art history , engineering , family medicine , marine engineering
General one-compartment model equations for computing peak drug concentrations following uniform and nonuniform dosing are discussed. Evidence is presented to confirm that time of peak concentration times (tmax) following oral or intramuscular dosing may be highly variable when doses, dosing intervals, or drug elimination rates are changing. A new tmax equation (t delta max) is presented which can provide correct times for peak concentrations under both fixed and variable dosing, and can be used when other tmax equations apply. Clinical examples involving its application are shown.