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Bioavailability of Valproic Acid Under Fasting/ Nonfasting Regimens
Author(s) -
CHUN A. H. C.,
HOFFMAN D. J.,
FRIEDMANN N.,
CARRIGAN P. J.
Publication year - 1980
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1980.tb01663.x
Subject(s) - bioavailability , pharmacokinetics , meal , regimen , valproic acid , absorption (acoustics) , pharmacology , drug , capsule , medicine , epilepsy , biology , physics , botany , psychiatry , acoustics
Valporic acid absorption was faster from a syrup than from a capsule form. Peak serum levels occurred with an hour with the syrup formulation. The drug was absorbed more rapidly when administered fasting and immediately before meal compared with immediately after meal. The extent of absorption from each formulation and for each meal regimen was similar. Pharmacokinetic evaluation of the data indicate a serum half-life of 12 hours.