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Streptozotocin (NSC‐85998) in Children with Acute Lymphocytic Leukemia. A Southwest Oncology Group Study
Author(s) -
DYMENT PAUL G.,
IYER RATHI V.,
MORGAN SAMUEL K.,
SEXAUER CHARLES L.
Publication year - 1979
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1979.tb02496.x
Subject(s) - medicine , streptozotocin , oncology , acute lymphocytic leukemia , leukemia , lymphoblastic leukemia , diabetes mellitus , endocrinology
Streptozotocin (NSC-85998), a nitrosourea antibiotic, was given to 18 children with acute lymphocytic leukemia in relapse in a dose of 500 mg/m2/day intravenously every day for five days. There were no responses in 14 fully evaluable patients. The principal toxicity consisted of gastrointestinal disturbances. Based on our findings and those of others in adults, steptozotocin appears to play no role in the management of acute lymphocytic leukemia.