Premium
Effect of Furosemide on Serum Clearance and Renal Excretion of Digoxin
Author(s) -
TSUTSUMI ETSURO,
FUJIKI HIROSHI,
TAKEDA HARUO,
FUKUSHIMA HIDEO
Publication year - 1979
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1979.tb01652.x
Subject(s) - furosemide , digoxin , diuretic , diuresis , endocrinology , excretion , renal function , medicine , urine , renal physiology , chemistry , heart failure
Serum turnover and urinary excretion of digoxin with or without oral furosemide were studied in six healthy subjects who received 0.006 mg/kg body weight digoxin intravenously. During furosemide treatment, the total amount of urinary digoxin did not change but the digoxin clearance during the diuretic phase and the digoxin excretion after the diuresis decreased significantly. The average serum half-life was prolonged from 37 hours in the control period to 86 hours in the furosemide period. Decreased glomerular filtration rate by volume depletion might have been responsible for the decreased excretion of digoxin, but there was no significant difference in urine volume after diuresis between the two periods, suggesting the possibility of inhibition of tubular secretion of digoxin by furosemide. It is also possible that serum digoxin concentration may be elevated if furosemide were given more frequently.