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High‐Dose Furosemide in Nigerians with Severe Chronic Renal Failure: Effect on Fecal Water Content
Author(s) -
MABADEJE A. F. BIOLA
Publication year - 1978
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1978.tb02431.x
Subject(s) - furosemide , medicine , edema , nigerians , chronic renal failure , gastroenterology , renal function , diuretic , gastrointestinal tract , political science , law
The effect of high doses of furosemide, 200 to 800 mg daily, has been studied in 12 Nigerias with edema associated with severe chronic renal failure and hypertension. They all responded well and lost their edema fluid during a period which varied from 10 to 57 days. The fecal water content and the frequency of bowel opening while on furosemide were significantly higher than without furosemide in six of these patients. It is concluded that the gastrointestinal tract is a major contributory site of fluid loss in patients with grossly impaired renal function.