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Pharmacologic Studies with Cefaclor, a New Oral Cephalosporin
Author(s) -
MEYERS BURT R.,
HIRSCHMAN SHALOM Z.,
WORMSER GARY,
GARTENBERG GARY,
SRULEVITCH ELINA
Publication year - 1978
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1978.tb01590.x
Subject(s) - cefaclor , cephalosporin , urine , ingestion , medicine , microgram , pharmacology , drug , cephalosporin antibiotic , pharmacokinetics , oral administration , chemistry , antibiotics , biochemistry , in vitro
Cefaclor, a new oral cephalosporin, was administered to 18 normal human volunteers in either single or multiple doses of 250 and 500 mg. Mean serum concentrations of 6.09 and 12.8 microgram/ml were achieved 1 hour after single oral doses of 250 and 500 mg, respectively. The serum concentrations declined rapidly and no drug was detected at 4 hours. Very high concentrations of cefaclor were found in urine during the first 8 hours after ingestion of the drug. Forty-three per cent of the total dose was excreted in urine during the first 8 hours. There was no accumulation of drug in serum during the multiple-dose studies.