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Displacement of Bilirubin from Albumin by Indomethacin
Author(s) -
RASMUSSEN L. FRASER,
AHLFORS CHARLES E.,
WENNBERG RICHARD P.
Publication year - 1978
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1978.tb01575.x
Subject(s) - bilirubin , albumin , dose , medicine , serum albumin , pharmacology , drug , serum bilirubin , plasma protein binding , chemistry , endocrinology
The primary albumin binding site of indomethacin is remote from the bilirubin binding site. Indomethacin is, at most, a weak displacer of bilirubin at low serum drug concentrations. When administered at dosages less than 1 mg/kg, indomethacin would appear to be safe with respect to serum binding of bilirubin in premature infants.