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Hemodynamic Effects of Morphine in Cardiac Disease
Author(s) -
GOULD LAWRENCE,
REDDY C. V. RAMANA,
OH KEUN CHANG,
KIM SOO GYUM,
BECKER WILLIAM H.
Publication year - 1978
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1978.tb01570.x
Subject(s) - medicine , intracardiac injection , morphine , cardiac index , anesthesia , hemodynamics , myocardial infarction , brachial artery , cardiac output , cardiology , blood pressure , cardiac catheterization , mean arterial pressure , heart rate
The hemodynamic effects of intravenous morphine were documented by right heart catheterization in six patients with an acute uncomplicated transmural myocardial infarction one to three days after the onset of symptoms. Intracardiac pressures, brachial artery pressure, and cardiac output were determined before and 15 minutes after the termination of the morphine infusion. Five milligrams morphine was given intravenously over a 10-minute period. The brachial artery pressure fell from a mean of 78 to a mean of 73 mm Hg (NS). As a result or morphine administration, the average cardiac index decreased from 2.68 to 2.31 liters/min-m2 (P is less than 0.05), and the stroke index decreased from 27 to 22 ml/beat-m2 (P is less than 0.05). Only small changes were observed in the intracardiac pressures.