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Double‐Blind Crossover Clinical Pharmacology Study Comparing Moxestrol (R 2858) and Ethinyl Estradiol in Postmenopausal Women
Author(s) -
ROBYN C.,
VEKEMANS M.,
ROZENCWEIG M.,
CHIGOT D.,
RAYNAUD J. P.
Publication year - 1978
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1978.tb01557.x
Subject(s) - postmenopausal women , crossover study , pharmacology , medicine , clinical pharmacology , double blind , double blind study , alternative medicine , pathology , placebo
The potency of 5 migrogram moxestrol (R 2858). 11beta-methoxy-17alpha-ethinyl-estra-1,3,5-[10]-triene-3,17-diol, administered orally, was compared to that of 25 microgram ethinyl estradiol in a double-blind crossover clinical pharmacology study of six postmenopausal women. At these doses, both compounds increased the eosinophilic index and decreased serum LH and FSH levels. A marked effect on circulating prolactin was observed only during ethinyl estradiol treatment.