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Double‐Blind Comparison of Triamterene Plus Hydrochlorothiazide and Spironolactone Plus Hydrochlorothiazide in the Treatment of Hypertension
Author(s) -
COCKE THOMAS B.,
FISCH SOLOMON,
GILMORE HUGH R.,
OKUN RONALD,
TAMAGNA IRENE G.,
WIPPLINGER KARL
Publication year - 1977
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1977.tb04613.x
Subject(s) - hydrochlorothiazide , triamterene , spironolactone , medicine , pharmacology , blood pressure , urology , adverse effect , diuretic , thiazide , essential hypertension , endocrinology , heart failure
The results from this double-blind, multi-investigator study showed that a combination of 50 mg triamterene plus 25 mg hydrochlorothiazide and a combination of 25 mg spironolactone plus 25 mg hydrochlorothiazide were equally efficacious in lowering blood pressure in hypertensive outpatients, and that they produced the same type and incidence of adverse effects. Likewise, the two drug combinations produced similar effects on blood chemistry and hematology. There were no significant differences between the two combination drugs in efficacy laboratory studies, or adverse effects.