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A Double‐Blind Comparison of Meptazinol with Placebo in Postoperative Pain
Author(s) -
HEDGES ANNMARIE,
ROSE JANET,
LEIGHTON MONICA,
TURNER PAUL
Publication year - 1977
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1977.tb04598.x
Subject(s) - medicine , placebo , anesthesia , analgesic , clinical trial , double blind , alternative medicine , pathology
In a double-blind clinical trial, meptazinol (400-mg capsules) was shown to be significantly better than placebo in relieving postoperative pain in patients who had under gone total abdominal hysterectomy operations. Analgesic activity was assessed by patients rating their pain before and 1 hour after the administration of each treatment, by sequential analysis of patient and investigator preference for treatment, and by calculating the time interval between doses of the two treatments.