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Absorption and Biotransformation of Cholecalciferol in Drug‐Induced Osteomalacia
Author(s) -
MATHESON R. T.,
HERBST J. J.,
JUBIZ W.,
FRESTON J. W.,
TOLMAN K. G.
Publication year - 1976
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1976.tb02417.x
Subject(s) - osteomalacia , biotransformation , cholecalciferol , drug , medicine , pharmacology , pharmacokinetics , chemistry , endocrinology , vitamin d and neurology , biochemistry , enzyme
The gastrointestinal absorption of vitamin D3 and its biotransformation to 25-hydroxycholecalciferol was studied in patients with drug-induced osteomalacia. The mean coefficient of absorption was virtually identical in the drug-treated group (82.8%) and the control (83.8%). The biotransformation of vitamin D3 to 25-hydroxycholecalciferol was significantly accelerated (P less than 0.03) in the drug-treated group compared to the control group. These data suggest that vitamin D absorption is not significantly altered but that biotransformation of vitamin D3 to 25-hydroxycholecalciferol is accelerated in drug-induced osteomalacia.