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Antiinflammatory Drugs and Gastrointestinal Bleeding: A Comparison of Aspirin and Ibuprofen
Author(s) -
SCHMID FRANK R.,
CULIC DASHA D.
Publication year - 1976
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1976.tb02416.x
Subject(s) - medicine , aspirin , connective tissue , ibuprofen , section (typography) , family medicine , library science , pathology , pharmacology , computer science , operating system
Gastrointestinal blood loss provoked by short-term and long-term therapy with aspirin and ibuprofen was compared in patients with rheumatoid arthritis. Blood loss was assessed by isotope counting of four-day stool collections after infusion of 51Cr-labeled autologous erythrocytes. After two weeks on drug or after one year on drug, aspirin consistently caused more bleeding than ibuprofen.