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An Evaluation of Papaverine in Tardive Dyskinesia
Author(s) -
GARDOS GEORGE,
COLE JONATHAN O.,
SNIFFIN CELIA
Publication year - 1976
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1976.tb02409.x
Subject(s) - tardive dyskinesia , papaverine , dyskinesia , medicine , anesthesia , movement disorders , blockade , pharmacology , psychiatry , receptor , schizophrenia (object oriented programming) , disease , parkinson's disease
An evaluation of papaverine was carried out in nine hospitalized chronic patients with moderate to servere tardive dyskinesia. Changes in movements were assessed on the Simpson and AIMS scales by two trained rates blind to the study design. Results showed a modest 20-25 per cent improvement in oral dyskinesia, but only two of the nine patients showed clinically obvious improvements in their movement disorders. No drug-induced side effects were found. The mechanism of pharmacologic action of papaverine in movement disorders needs to be clarified, but dopamine receptor blockade may be primarily involved.