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Naproxen Plasma Levels in Volunteers After Single‐Dose Administration by Oral and Rectal Routes
Author(s) -
DESAGER J. P.,
VANDERBIST M.,
HARVENGT C.
Publication year - 1976
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1976.tb01516.x
Subject(s) - naproxen , suppository , bioavailability , rectal administration , plasma concentration , oral administration , pharmacokinetics , pharmacology , plasma levels , dosage form , chromatography , chemistry , medicine , alternative medicine , pathology
The bioavailability (plasma concentrations, AUC) of a rectal formulation (suppository) of naproxen was investigated in six healthy volunteers by comparison with an oral preparation (tablets). Plasma half-lives after both formulations were identical 10 hr 15 min+/-25 min (S.D.). Determined by the AUC the bioavailability of naproxen in the suppositories was 94.8%+/-6.3% of the bioavailability of naproxen in the tablets. This paper describes also a new gas-liquid chromatographic method for determining unchanged naproxen in human plasma which is quick, sensitive, and specific.