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Correlation of Serum Creatinine Concentration and Amikacin Half‐Life
Author(s) -
LEVY JACK,
KLASTERSKY JEAN
Publication year - 1975
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1975.tb05924.x
Subject(s) - amikacin , medicine , section (typography) , university hospital , library science , family medicine , computer science , chemistry , advertising , antibiotics , business , biochemistry
The half-life of amikacin in serum has been measured following the administration of a single intravenous injection of 7 mg/kg in nine adult patients with varying degrees of renal function impairment and in four patients with normal renal function. A linear relationship between the half-life and the serum concentration has been found, suggesting that half-life of amikacin in serum can be calculated by multiplying the serum creatinine (in mg/100 ml) by 3.