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Plasma Levels of a New Pelletized Form of Amitriptyline for Maintenance Therapy
Author(s) -
HUCKER H. B.,
STAUFFER S. C.,
CLAYTON F. G.,
NAKRA B. R. S.,
GAIND R.
Publication year - 1975
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1975.tb02352.x
Subject(s) - amitriptyline , nortriptyline , dosing , dosage form , capsule , plasma levels , plasma concentration , pharmacology , medicine , anesthesia , botany , biology
Plasma levels of amitriptyline and nortriptyline were measured in volunteers after one week of daily dosage with either 25 mg t.i.d. of standard amitriptyline tablets or a single 75-mg capsule of a new pelletized form of amitriptyline. Concentrations of both compounds were essentially equal at the end of one week's dosage with either dosage form but were somewhat higher throughout the dosing time interval for the pelletized drug.