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Loading and Maintenance Doses of Digoxin in Patients with Normal Renal Function and Those with Severely Impaired Renal Function
Author(s) -
WAGNER JOHN G.
Publication year - 1974
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1974.tb01408.x
Subject(s) - medicine , digoxin , clinical pharmacology , renal function , pharmacy , library science , pharmacology , family medicine , computer science , heart failure
T HE clinician may find the equations and terminology in this report confusing and difficult to follow. However, pharinacokinetic theory is of little use unless those familiar with the theory show how application of the theory is of practical importance. This paper is an attempt to do so with a drug that has presented many problems with respect to dosing and toxicity. It is really not important that the clinician completely understand how the results were calculated; it is important for him or her to remember the results for each drug for which the equations were applied. The arguments are presented in the text, and the equations in the Appendix, so that those familiar with pharmacokinetic theory can apply them to other drugs and produce still more practical information for the busy clinician. The principal role of the clinician, with respect to the aspect of medicine discussed in this report, is to determine the relationship between clinical effect and dose of a drug. The principal roles of the pharmaco-