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Some Clinical and Physiologic Effects of a Thioxanthene Derivative, Thiothixene (P‐4657B), in 20 Newly Hospitalized Male Schizophrenics
Author(s) -
HEKIMIAN LEON J.,
GERSHON SAMUEL,
FLOYD ARTHUR
Publication year - 1967
Publication title -
the journal of clinical pharmacology and the journal of new drugs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0095-9863
DOI - 10.1002/j.1552-4604.1967.tb00030.x
Subject(s) - medicine , derivative (finance) , pharmacology , pediatrics , economics , financial economics
This study was designed to evaluate some of the effects of a new thioxanthene, thiothixene (P-4657B), in 20 male schizophrenic patients recently admitted to Bellevue Hospital. The results of a dosage range trial indicated that at a dosage of approximately 50 mg per day, toxic and side effects as well as therapeutic effects were at their maximum. Parkinsonian reactions (in 17 of 20 patients) with restlessness and akathisia were the most prominent of these effects. Also, activation of psychopathology was observed in six of 20 subjects. Thiothixine did exhibit some antipsychotic activity, but it does not appear to be as valuable as it has been reported to be in chronic schizophrenic patients.