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Comparative Subchronic Toxicity of Chlorine and Monochloramine in the B6C3F1 Mouse
Author(s) -
Daniel F. Bernard,
Ringhand H. Paul,
Robinson Merrell,
Stober Judy A.,
Olson Greg R.,
Page Norbert P.
Publication year - 1991
Publication title -
journal ‐ american water works association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.466
H-Index - 74
eISSN - 1551-8833
pISSN - 0003-150X
DOI - 10.1002/j.1551-8833.1991.tb07251.x
Subject(s) - histopathology , toxicity , chlorine , hematology , physiology , gross examination , toxicology , pathology , chemistry , medicine , biology , organic chemistry
Separate groups of male and female B6C3F1 mice were administered chlorine and monochloramine in drinking water for 90 consecutive days. Both disinfectants were supplied at 12.5, 25, 50, 100, and 200 mg/L. Criteria evaluated included mortality, clinical signs, body weight, food consumption, hematology, clinical chemistry, organ weights, gross pathology, and histopathology. Overall, the correlation of the biochemical, hematological, and organ weight data, in the absence of histopathology and observable clinical signs of toxicity, suggests that the chlorine and monochloramine induced effects via an indirect mechanism, e.g., nutritional deficiencies, rather than a direct toxicological effect on specific organs or tissues.