Open AccessCholecystokinin Decreases Food Intake in Rats 1
Author(s) -
Gibbs James,
Young Robert C.,
Smith Gerard P.
Publication year - 1997
Publication title -
obesity research
Language(s) - English
Resource type - Journals
eISSN - 1550-8528
pISSN - 1071-7323
DOI - 10.1002/j.1550-8528.1997.tb00305.x
Subject(s) - cholecystokinin , endocrinology , medicine , secretin , hormone , food intake , chemistry , gastrointestinal hormone , oxytocin , peptide hormone , taste aversion , neuropeptide , taste , secretion , food science , receptor
Partially purified cholecystokinin (CCK) was injected intraperitoneally into fasted rats prior to food presentation. The hormone produced a large doserelated suppression of intake of solid and liquid diets. Identical doses of the synthetic terminal octapeptide of cholecystokinin produced identical results. An effective dose of CCK did not suppress drinking after water deprivation. Treated animals did not appear ill and were not hyperthermic; neither CCK nor the octapeptide produced learning of a taste aversion in bait‐shyness tests. The effect of CCK is not a property of all gut hormones, since injections of secretin did not affect feeding. These studies raise the possibility that CCK plays an inhibitory role in the short‐term control of feeding behavior.