Open AccessDuration of Improved Muscle Glucose Uptake After Acute Exercise in Obese Zucker Rats
Author(s) -
Betts Jeffery J.,
Sherman William M.,
Reed Michael J.,
Gao Jiaping P.
Publication year - 1993
Publication title -
obesity research
Language(s) - English
Resource type - Journals
eISSN - 1550-8528
pISSN - 1071-7323
DOI - 10.1002/j.1550-8528.1993.tb00624.x
Subject(s) - medicine , endocrinology , insulin , basal (medicine) , glucose uptake , insulin resistance , skeletal muscle , carbohydrate metabolism
Skeletal muscle is insulin resistant in the obese Zucker rat. Endurance training reduces muscle insulin resistance, but the effects of a single acute exercise session on muscle insulin resistance in the obese Zucker rat are unknown. Therefore, insulin responsiveness of muscle glucose uptake was measured in 15‐week‐old obese rats either 1, 48, or 72 hours after two hours of intermittent exercise (3030 min; work:rest). Hindlimbs of sedentary lean (LS) and obese (OS) rats and exercised obese (OE) rats were perfused after a 10‐hour fast under both basal (0 mU.ml −1 ) and maximal (20 mU.ml −1 ) insulin concentrations to measure net glucose uptake. Insulin responsiveness of net glucose uptake was significantly reduced in OS compared to LS (8.5 ± 1.6 vs 15.3 ± 2.0 μmol.g −1 .h −1 , respectively). Compared to OS, insulin responsiveness of net glucose uptake was significantly increased by 56% and 80% at 1 hour and 48 hours after acute exercise. However, 72 hours after acute exercise, the increased insulin responsiveness of net glucose uptake was no longer evident. These results indicate that improved responsiveness of muscle glucose uptake persists for at least 48 hours after two hours of acute intermittent exercise in 15‐week‐old obese Zucker rats. (OBESITY RESEARCH 1993; 1:295–302)