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ADAPTATION IN PANTOTHENATE ‐ REQUIRING NEUROSPORA. I. A GENE MODIFYING PANTOTHENATE MUTANTS
Author(s) -
Davis Rowland H.
Publication year - 1960
Publication title -
american journal of botany
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.218
H-Index - 151
eISSN - 1537-2197
pISSN - 0002-9122
DOI - 10.1002/j.1537-2197.1960.tb07136.x
Subject(s) - mutant , biology , neurospora , neurospora crassa , gene , limiting , genetics , adaptation (eye) , mechanical engineering , neuroscience , engineering
D avis, r . H. (California Inst. Tech., Pasadena.) Adaptation in pantothenate‐requiring Neurospora. i. a gene modifying pantothenate mutants. Amer. Jour. Bot. 4(5): 351–357. Illus. 1960.—a modified pantothenicless strain was isolated from a pan‐1, al‐1, A mycelium which had adapted to a limiting concentration of pantothenate. The modified and original strains differ by a single gene, m, which is not linked genetically to either of the 2 known pantothenic acid loci. The gene m appears to modify the uptake, rather than the synthesis, of pantothenate on the part of both pan‐1 and pan‐2 mutants. Neither pan mutant in combination with m grows on minimal medium. However, the pan‐1 m and pan‐2 m strains grow to a greater extent than pan‐1 or pan‐2 in limiting pantothenate concentrations. The mechanism of action of the m gene is discussed, and compared to modifiers of certain other mutant phenotypes of Neurospora .