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The COMT rs 4680 M et allele contributes to long‐lasting low back pain, sciatica and disability after lumbar disc herniation
Author(s) -
Jacobsen L.M.,
Schistad E.I.,
Storesund A.,
Pedersen L.M.,
Rygh L.J.,
Røe C.,
Gjerstad J.
Publication year - 2012
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1002/j.1532-2149.2011.00102.x
Subject(s) - sciatica , oswestry disability index , snp , medicine , low back pain , single nucleotide polymorphism , lumbar , genotype , anesthesia , physical therapy , surgery , pathology , genetics , gene , alternative medicine , biology
Background The COMT enzyme metabolizes catecholamines and thus modulates adrenergic, noradrenergic and dopaminergic signaling. A functional polymorphism in the gene encoding this enzyme, i.e. the COMT Val158Met SNP that reduces enzyme activity, has previously been linked to pain sensitivity. Methods We examined if the COMT Val158Met SNP could contribute to discogenic subacute low back pain and sciatica by comparing the frequency of the Val158Met genotypes of degenerative disc disease patients with healthy controls. Moreover, we examined if this SNP could predict the clinical outcome, i.e. the progression of pain and disability. Results The present data demonstrated that there were no differences in COMT genotype frequencies between the newly diagnosed patients and controls. Analysis of pain and disability in the patients over time revealed, however, a significant or border‐line significant increase in McGill sensory score and O swestry D isability I ndex ( ODI ) score for individuals with COMT Met/Met genotype. Furthermore, significant associations between the COMT Met‐allele and VAS activity score, McGill sensory score and ODI score were observed in the patients 6 months after inclusion. Discussion Although the Val158Met SNP was not a risk factor for disc herniation, patients with Met/Met had more pain and slower recovery than those with Val/Met , which in turn also had more pain and slower recovery than those with Val/Val suggesting the SNP contributes to the progression of the symptoms of disc herniation. Conclusion We conclude that the functional COMT Val158Met SNP contributes to long lasting low back pain, sciatica and disability after lumbar disc herniation.