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A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.
Author(s) -
Philipp S.,
Cavalié A.,
Freichel M.,
Wissenbach U.,
Zimmer S.,
Trost C.,
Marquart A.,
Murakami M.,
Flockerzi V.
Publication year - 1996
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1996.tb01004.x
Subject(s) - biology , transient receptor potential channel , microbiology and biotechnology , homologous chromosome , calcium , genetics , drosophila (subgenus) , voltage dependent calcium channel , drosophila melanogaster , gene , medicine , receptor
Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP3)‐mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry. Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP3 or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP3 signalling.