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Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle ‘start’ function of Res2‐Cdc10.
Author(s) -
Nakashima N.,
Tanaka K.,
Sturm S.,
Okayama H.
Publication year - 1995
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1995.tb00161.x
Subject(s) - library science , biology , computer science
In the yeast cell cycle ‘start’ requires sets of the Cdc10/ SWI family of transcriptional factors which activate the MCB cis elements contained in genes essential for S phase progression. Fission yeast possess two such overlapping systems, Res1‐Cdc10 and Res2‐Cdc10, both of which act to start the mitotic and meiotic cycles. We have recently isolated rep2+ as a multicopy suppressor of a temperature‐sensitive cdc10 mutant which encodes a zinc finger protein. Here we show that the Rep2 zinc finger protein is an essential component of the active Res2‐Cdc10 transcriptional regulator complex and likely to play a role in the control of cell cycle ‘start’. Our data suggest that Rep2 is a transcriptional activator subunit which interacts with the MCB binding subunit complex formed by Res2 and Cdc10.