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p60v‐src causes tyrosine phosphorylation and inactivation of the N‐cadherin‐catenin cell adhesion system.
Author(s) -
Hamaguchi M.,
Matsuyoshi N.,
Ohnishi Y.,
Gotoh B.,
Takeichi M.,
Nagai Y.
Publication year - 1993
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1993.tb05658.x
Subject(s) - mechanism (biology) , library science , cadherin , biology , cell , genetics , computer science , philosophy , epistemology
Transformation of chick embryonic fibroblasts with Rous sarcoma virus strongly suppresses N‐cadherin‐mediated cell‐cell adhesion, without inhibiting its expression. This suppression is correlated with tyrosine phosphorylation of N‐cadherin and catenins, the cadherin‐associated proteins, which are known to regulate cadherin function. Experiments with non‐myristylation and temperature‐sensitive mutants of RSV and with herbimycin A, a potent inhibitor of tyrosine kinases, suggest that both the suppression of cell adhesion and tyrosine phosphorylation of catenins are highly transformation‐specific.