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Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac‐1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA‐1.
Author(s) -
Bretscher M.S.
Publication year - 1992
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1992.tb05068.x
Subject(s) - beta (programming language) , alpha (finance) , alpha v beta 3 , integrin , biology , microbiology and biotechnology , biochemistry , cell , medicine , vitronectin , construct validity , nursing , computer science , patient satisfaction , programming language
The alpha 5 beta 1, alpha 6 beta 4 and Mac‐1 integrins all participate in the endocytotic cycle. By contrast, alpha 3 beta 1, alpha 4 beta 1 and LFA‐1 do so much more slowly, or not at all, in the cell lines examined. This indicates that the alpha‐chains appear to determine whether an integrin cycles or not, and that alpha 5 beta 1, alpha 6 beta 4 and Mac‐1 can be brought to the leading edge of a moving cell by endocytosis and recycling.