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Cells can use their transferrin receptors for locomotion.
Author(s) -
Bretscher M.S.
Publication year - 1992
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1992.tb05066.x
Subject(s) - biology , transferrin , transferrin receptor , receptor , microbiology and biotechnology , computational biology , genetics , biochemistry
Cells of the B lymphoblastoid cell line JY attach to substrata made of antibodies to the transferrin receptor. Many of these attached cells migrate considerable distances. JY cells also attach to an anti‐integrin substratum (anti LFA‐1), but on this surface they do not migrate. These results suggest that a circulating receptor‐‐the transferrin receptor‐‐can be used for locomotory purposes, whereas LFA‐1, which is not endocytosed in these cells, cannot be used for locomotion. This indicates that the endocytotic cycle can drive cell locomotion.