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Blockade of transgenic gamma delta T cell development in beta 2‐microglobulin deficient mice.
Author(s) -
Pereira P.,
Zijlstra M.,
McMaster J.,
Loring J.M.,
Jaenisch R.,
Tonegawa S.
Publication year - 1992
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1992.tb05023.x
Subject(s) - biology , blockade , beta (programming language) , transgene , beta 2 microglobulin , genetically modified mouse , microbiology and biotechnology , immunology , genetics , receptor , gene , computer science , programming language
The gamma delta T cell receptor (TCR) of the hybridoma KN6 recognizes the self molecule encoded by a class I gene which maps within the TL region of the major histocompatibility complex (MHC) of H‐2b mice. Mice transgenic (Tg) for this TCR were crossed with mice genetically deficient in beta 2‐microglobulin (beta 2m). No mature Tg gamma delta T cells were detected in the thymus or the spleen of the beta 2m‐ gamma delta Tg mice. We conclude that interaction between the Tg gamma delta TCR and a beta 2m‐associated molecule (probably an MHC class I molecule) is required for the generation of mature Tg gamma delta T cells.