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Unregulated expression of c‐Jun or c‐Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells.
Author(s) -
Doucas V.,
Spyrou G.,
Yaniv M.
Publication year - 1991
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1991.tb07760.x
Subject(s) - biology , c jun , cancer research , breast cancer , receptor , oestrogen receptor , c fos , microbiology and biotechnology , gene expression , cancer , transcription factor , gene , genetics
We present evidence that oestrogen receptor activity in human MCF‐7 breast cancer cells is reduced by over‐expression of c‐Jun or c‐Fos proteins and to a lesser extent by Jun B overexpression. In contrast, overexpression of Jun D protein does not affect the activity of the oestrogen receptor. A region of c‐Jun found to be required for repression of oestrogen receptor activity is located outside the DNA binding domain and is not conserved among the three Jun proteins. Finally, we suggest that c‐Jun and c‐Fos act independently to inactivate the oestrogen receptor.