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A fusion protein formed by L‐myc and a novel gene in SCLC.
Author(s) -
Mäkelä T.P.,
Saksela K.,
Evan G.,
Alitalo K.
Publication year - 1991
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1991.tb07652.x
Subject(s) - library science , biology , virology , gene , genetics , computer science
Oncogenic activation of myc genes in human cancer involves deregulated expression of myc proteins with no major structural alterations. Here two independent small cell lung carcinoma (SCLC) cell lines were found to express similar novel proteins antigenically related to L‐myc. cDNAs corresponding to these proteins were cloned and shown to encode chimeric polypeptides with amino‐terminal sequences from a novel gene named rlf joined to the L‐myc protein. Although the chimeric mRNAs were shown to be identical, they result from distinct DNA rearrangements. The L‐myc fusion protein may represent another activation mechanism of the myc proto‐oncogenes.