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An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.
Author(s) -
Boehm T.,
Greenberg J.M.,
Buluwela L.,
Lavenir I.,
Forster A.,
Rabbitts T.H.
Publication year - 1990
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1990.tb08183.x
Subject(s) - biology , exon , gene , genetics , conserved sequence , messenger rna , start codon , methylation , promoter , chromosomal translocation , peptide sequence , gene expression , microbiology and biotechnology
We previously identified a putative T cell oncogene on chromosome 11 near a translocation t(11;14)(p15;q11) in a human T cell tumour. The gene is transcribed from distinct promoters which have unrelated sequences, which occur within close but distinct methylation‐free islands and which allow cell specific production of mRNA. The alternative first exons each contain a protein initiation codon from which two species of protein can be made, differing by only a single amino acid. The protein sequence is highly conserved between man and mouse (98%) and the same single codon difference between alternative first exons is also conserved. This is, therefore, a new form of eukaryotic gene organization from which similar proteins can be made from distinct mRNA species.