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PEA3 is a nuclear target for transcription activation by non‐nuclear oncogenes.
Author(s) -
Wasylyk C.,
Flores P.,
Gutman A.,
Wasylyk B.
Publication year - 1989
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1989.tb08500.x
Subject(s) - biology , transcription (linguistics) , transcription factor , genetics , cell nucleus , nuclear protein , microbiology and biotechnology , computational biology , gene , philosophy , linguistics
We have found that the activity of the transcription factor PEA3 is regulated by the expression of non‐nuclear oncogenes. This factor, although distinct from PEA1 (AP1), is activated by the same oncogenes (v‐src, polyoma (Py) middle T, c‐Ha‐ras, v‐mos, v‐raf), by tetradecanoyl phorbol‐acetate (TPA) and by serum components. We present evidence that PEA3 and PEA1 co‐operate in the response of the polyoma virus (Py) alpha domain to oncogene expression. However, in contrast to PEA1, c‐fos does not appear to be necessary for activation of PEA3, suggesting that PEA3 is a fos independent target for regulation of transcription by non‐nuclear oncogenes.