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A B‐lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
Author(s) -
Stamenkovic I.,
Clark E. A.,
Seed B.
Publication year - 1989
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1989.tb03521.x
Subject(s) - biology , nerve growth factor , receptor , lymphocyte , cancer research , lymphocyte activation , immunology , microbiology and biotechnology , immune system , genetics , t cell
B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B‐cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma‐interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.