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DNA‐dependent RNA polymerase of Escherichia coli induces bending or an increased flexibility of DNA by specific complex formation.
Author(s) -
Heumann H.,
Ricchetti M.,
Werel W.
Publication year - 1988
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1988.tb03336.x
Subject(s) - rna polymerase , dna , planck , escherichia coli , flexibility (engineering) , rna , biology , polymerase , physics , microbiology and biotechnology , dna polymerase , genetics , gene , quantum mechanics , mathematics , statistics
Escherichia coli RNA polymerase is shown to induce bending or an increased flexibility of the promoter DNA. This is a specific effect of holoenzyme (core enzyme and sigma‐factor). The centre of the flexibility is 3 bp upstream of the initiation point of RNA synthesis. This flexibility or bending is maintained during RNA synthesis by core enzyme.