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A new type of transforming growth factor‐beta, TGF‐beta 3.
Author(s) -
Derynck R.,
Lindquist P. B.,
Lee A.,
Wen D.,
Tamm J.,
Graycar J. L.,
Rhee L.,
Mason A. J.,
Miller D. A.,
Coffey R. J.
Publication year - 1988
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1988.tb03257.x
Subject(s) - library science , biology , miller , computer science , ecology
A new type of TGF‐beta, TGF‐beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF‐beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF‐beta 3 gene is spread over seven exons as in the case of the TGF‐beta 1 gene. Comparison with TGF‐beta 1 and ‐beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF‐beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs‐beta.