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Evidence that the Abdominal‐B r element function is conferred by a trans‐regulatory homeoprotein.
Author(s) -
DeLorenzi M.,
Ali N.,
Saari G.,
Henry C.,
Wilcox M.,
Bienz M.
Publication year - 1988
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1988.tb03189.x
Subject(s) - library science , biology , computer science
The Abdominal‐B gene is a homeotic gene located in the distal‐most region of the bithorax complex (BX‐C). Based on complementation analysis it has been proposed that the gene contains two separable genetic elements, called the m and r elements. The r element has a chiefly regulatory function confined to parasegment 14. In a reverse Northern screen of the distal‐most BX‐C DNA, we found four distinct areas that are transcribed in the embryo. One of the transcripts spans a large genomic region which, upon disruption by rearrangement breakpoints, causes loss of r element function. This transcript is expressed in the early embryo in a single domain apparently corresponding to parasegment 14. We propose that the small homeoprotein encoded by the transcript acts as a trans‐regulator to confer r element function.