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Seventy‐kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M13 procoat protein into microsomes.
Author(s) -
Zimmermann R.,
Sagstetter M.,
Lewis M. J.,
Pelham H. R.
Publication year - 1988
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1988.tb03144.x
Subject(s) - kilodalton , biology , reticulocyte , heat shock protein , lysis , microsome , shock (circulatory) , biochemistry , enzyme , messenger rna , medicine , gene
Processing of M13 procoat protein, synthesized in a bacterial cell‐free extract, to transmembrane coat protein by dog pancreas microsomes is stimulated by a system which is present in rabbit reticulocytes and depends on nucleoside triphosphates. This system consists of (at least) two components which act synergistically: members of the 70‐kd heat shock protein family and (at least) one additional component. This component depends on ATP (or GTP) for its action.