Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients. | Zendy

Anson D. S. | Zendy; Blake D. J. | Zendy; Winship P. R. | Zendy; Birnbaum D. | Zendy; Brownlee G. G. | Zendy

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Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients.

Author(s) -

Anson D. S.,

Blake D. J.,

Winship P. R.,

Birnbaum D.,

Brownlee G. G.

Publication year - 1988

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.1002/j.1460-2075.1988.tb03134.x

Subject(s) - biology , gene , genetics , microbiology and biotechnology , mcf 7 , cancer , human breast , cancer cell

The mcf.2 transforming gene sequence has been located to the region between 29 and 61 kb 3′ of the factor IX gene. Two unrelated haemophilia B patients who raise antibodies to infused factor IX (‘inhibitors’) have deletions in excess of 273 kb encompassing the factor IX and mcf.2 genes and a CG‐rich island. We believe these patients show the first nullisomic deletion of a transforming gene to be reported. No clinical condition can be attributed to the loss of the mcf.2 gene.

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