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Complex rearrangements within the human J delta‐C delta/J alpha‐C alpha locus and aberrant recombination between J alpha segments.
Author(s) -
Baer R.,
Boehm T.,
Yssel H.,
Spits H.,
Rabbitts T. H.
Publication year - 1988
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1988.tb02993.x
Subject(s) - biology , genetics , microbiology and biotechnology
We have examined DNA rearrangements within a 120 kb cloned region of the human T cell receptor J delta‐C delta/J alpha‐C alpha locus. Three types of pattern emerge from an analysis of T cell lines and clones. Firstly, cells with two rearrangements within J delta‐C delta; secondly, cells with one rearrangement within J delta‐C delta and one or more J alpha rearrangements, and finally, cells with rearrangements within J alpha and consequential deletion of the delta locus. Further analysis by cloning of rearrangements within the J alpha locus show that, in addition to V alpha‐J alpha joins, J alpha‐J alpha aberrant recombinations occur and rearrangement data indicate that such events are frequent. A model is presented to account for such recombinations.