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Dual regulation of the expression of the polyubiquitin gene by cyclic AMP and heat shock in yeast.
Author(s) -
Tanaka K.,
Matsumoto K.,
Tohe A.
Publication year - 1988
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1988.tb02837.x
Subject(s) - yeast , fermentation , cycloheximide , biology , gene , heat shock protein , gene expression , microbiology and biotechnology , genetics , biochemistry , protein biosynthesis
The expression of the polyubiquitin gene in yeast, UB14, is repressed by cAMP‐dependent protein phosphorylation. Since cycloheximide does not inhibit the induction of the UB14 transcription, no de novo protein synthesis is required in this process. The expression of the UB14 gene is also induced by mild heat shock by a mechanism other than depletion of cAMP. From the genetic analysis of the UB14 gene, we propose that the UB14 gene is one of the genes which are part of the cAMP‐effector pathway and required for G0/G1 arrest in Saccharomyces cerevisiae.